Although sensation-seeking status is associated with age of initiation and amount of drug use among adolescents, and sensitivity to the behavioral and reinforcing effects of drugs among young adults, it is unclear whether sensation-seeking status among adolescents is predictive of sensitivity to the pharmacological effects of drugs i. This study examined the acute behavioral effects of oral diazepam and d-amphetamine in young adults, ages 18—21 years, who had consistently scored in the highest or lowest third of their grade-based cohort on a modified Sensation Seeking Scale that was completed annually between ages 10 and 14 years. Healthy participants completed 16 7. Each day, assessments consisting of computer task performance, verbal report of drug effects, and cardiovascular measures were completed 0, 50, , , , and min after drug administration. Placebo and three active doses of diazepam and d-amphetamine 2. Typical stimulant and sedative effects were obtained with d-amphetamine and diazepam, respectively. Drug effects varied as a function of sensation-seeking status, with magnitude of effects on cardiovascular function, task performance, and report of positive drug effects being greater among high sensation seekers, and report of negative drug effects being greater among low sensation seekers.
Also on amitriptyline and sertraline. Peak effects occurred 50 min postdose in both low and high sensation seekers, although the magnitude of impairment was greater among high sensation seekers. Verbal report of drug effect measures Sedative-like reports were observed on the verbal-report scales. Aerobic fitness and opioidergic inhibition of cardiovascular stress reactivity. Email Address.
The aim of this study was to assess the relative bioavailability of diazepam after administration of diazepam itself or as a water-soluble prodrug, avizafone, in humans. The study was conducted in an open, randomized, single-dose, three-way, cross-over design. Each subject received intramuscular injections of avizafone 20 mg, diazepam The maximum concentration C max of diazepam after avizafone injection was higher than that obtained after injection of diazepam itself vs. Diazepam concentrations reached their maximal value faster after injection of avizafone. Injection of avizafone with atropine—pralidoxime AIBC had no effect on diazepam C max and AUC, but the time to C max was increased, relative to avizafone injected alone. According to the Akaike criterion, the pharmacokinetics of diazepam after injection as a prodrug was best described as a two-compartment with zero-order absorption model.